| Main Title |
Copy of - 2,4-pentanedione, in Vivo Mouse Micronucleus Study with Cover Letter dated 12/05/1986. |
| CORP Author |
Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1986 |
| Report Number |
89-870000070 |
| Stock Number |
OTS0510542-1 |
| Additional Subjects |
Toxicology ;
Health effects ;
2 ;
4-pentanedione ;
Genotoxicity ;
Chromosomal Effects ;
Mammals ;
Mice ;
Parenteral ;
Intraperitoneal ;
Toxic substances ;
Laboratory animals ;
CAS No 123-54-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0510542-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
28p |
| Abstract |
2,4-Pentanedione was evaluated for the ability to increase the incidence of micronucleated polychromatic erythrocytes in bone marrow of male and female Swiss-Webster mice treated by single i.p. injection (Micronucleus Test). Groups of at least 10 mice (at least 5 males and 5 females) were injected with 2,4-pentanedione in water vehicle at doses of 0, 200, 400 or 650 mg/kg (high-dose = approximately 89% of the LD50). The peripheral blood was sampled for micronucleus evaluation 30, 48, and 72 hrs after dosing. The ratio of normochromatic to polychromatic erythrocytes was not significantly different (p > 0.05, Fisher's Exact Test) inthe treated groups compared with the vehicle controls. Statistically significant increases in the numbers of micronuclei were observed at the 30-hr sampling time for male and female mice at the mid- and high-dose levels (p < or = 0.001) and at the 48-hr sampling for the combined sexes at all treatment levels (low-dose level, p < 0.05, and mid- and high-dose, p < or = 0.001). |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1986 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801580 |
| Origin |
NTIS |
| Type |
CAT |
