Main Title |
Mutagenicity of Teflon-Coated Glass Fiber Filters: A Potential Problem and Solutions. |
Author |
Houk, V. S. ;
Zweidinger, R. B. ;
Claxton, L. D. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/213; |
Stock Number |
PB88-170626 |
Additional Subjects |
Toxicology ;
Fiberglass ;
Reprints ;
Teflon ;
Mutagenesis ;
Air pollution effects ;
Particulates
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-170626 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
Teflon-coated glass fiber filters, used in studies of airborne particulate matter, were tested for mutagenic activity using the Salmonella/mammalian-microsome (Ames) assay. For each sample, eight blank filters were simultaneously extracted with dichloromethane (DCM), and the extract was concentrated by rotary evaporation and a nitrogen purge. Samples were solvent exchanged into dimethylsulfoxide (DMSO) for bioassay. Mutagenicity testing was performed using tester strain TA98, with and without metabolic activation. Preliminary findings have indicated that both direct- and indirect-extracting frameshift mutagens were present on the blank filters. Pre-extracting the filters with DCM reduced the activity associated with the filters; however, forced-air baking enhanced the mutagenic response. Additional analyses have suggested that the interference caused by filter mutagenic is inversely proportional to extraction efficiency and particle load. |
Supplementary Notes |
Pub. in Environmental Science and Technology, v21 n9 p917-920 Sep 87. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Mutagenicity of Teflon-Coated Glass Fiber Filters: A Potential Problem and Solutions. |
PUB Date Free Form |
1987 |
Category Codes |
57Y; 68A |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
811327462 |
Origin |
NTIS |
Type |
CAT |