Main Title |
Phthalate Esters Program Panel Voluntary Test Program Health Effects Testing Phase I: Validation Results Volume One and Two with Cover Memo. |
Author |
Cox, G. V. ;
Moran, E. J. ;
Zoll, D. F. ;
|
CORP Author |
Chemical Manufacturers Association, Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Publisher |
30 Oct 1982 |
Year Published |
1982 |
Report Number |
FYI-AX-1282-0224; |
Stock Number |
OTS-0000224-0 |
Additional Subjects |
Health effects ;
Tests ;
Genotoxicity ;
Biological studies ;
Testing ;
Liver function tests ;
Phthalate esters ;
Metabolic studies ;
Liver structure
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS-0000224-0 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
839p |
Abstract |
The Chemical Manufacturers Association Phthalate Esters Program Panel submitted a voluntary test program under Section 4 of the Toxic Substances Control Act to the Environmental Protection Agency on October 30, 1981. Volume II of that submission dealt with health effects of phthalate esters. Notification of the Program's acceptability was given by the Agency on January 5, 1982. The Health Effects Program is intended to give guidance regarding the level of concern over health effects due to phthalates, prioritize phthalates for further testing in terms of the effects of concern, and initiate such further testing as may be appropriate. Three types of testing were conducted: genotoxicity tests, biological studies focusing on liver structure and function, and metabolic studies. Testing is proceeding in two phases; Phase I consists of genotoxicity and biological studies with reference materials to provide validation and optimization of the proposed tests. Phase II would be performed on phthalate esters chosen to be representative of the major structural classes. Metabolic studies on di-2-ethylhexyl phthalate (DEHP) were also undertaken simultaneously with Phase I. |
Supplementary Notes |
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Availability Notes |
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Category Codes |
57 |
NTIS Prices |
PC$132.50/MF$25.00 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
010000040 |
Origin |
NTIS |
Type |
CAT |