| Main Title |
Construction of a Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model for Carbofuran Using the Exposure Related Dose Estimating Model (ERDEM). |
| Author |
Zhang, X. ;
Tsang, A. M. ;
Okino, M. S. ;
Power, F. W. ;
Knaak, J. B. ;
|
| CORP Author |
Environmental Protection Agency, Research Triangle Park, NC. National Exposure Research Lab. |
| Publisher |
Oct 2006 |
| Year Published |
2006 |
| Report Number |
EPA/600/R-06/135; GS-35F-4357D; NERL-RTP-HEASD-06-155; |
| Stock Number |
PB2007-100680 |
| Additional Subjects |
Carbofuran ;
Health risks ;
Human exposure ;
Pesticides ;
Literature review ;
Risk assessment ;
Uncertainty analysis ;
Monte Carlo method ;
Physiologically Based Pharmacokinetic/Pharmacodynamic model ;
Exposure Related Dose Estimating Model ;
ADME(Absorption distribution metabolism elimination)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB2007-100680 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
234p |
| Abstract |
Carbofuran, known as 2, 3-dihydro-2, 2-dimethyl-7-benzofuranyl- N-methylcarbamate, is a broad spectrum N-methyl carbamate pesticide. Carbofuran and its metabolite, 3-hydroxycarbofuran, exert their toxicity by reversibly inhibiting acetylcholinesterase (AChE). Carbofuran is widely used in agriculture for pest control. Agricultural workers and the general population may beexposed to it by dermal contact, inhalation, or ingestion as a result ofits application or by food intake. To better characterize the human health risk caused by carbofuran exposure, a physiologically-based pharmacokinetic/ pharmacodynamic (PBPK/PD) model was developed in the Exposure Related Dose Estimating Model (ERDEM) system in order to facilitate an understanding of carbofuran's absorption, distribution, metabolism, elimination (ADME) processes, and AChE inhibition effects for the rat. To obtain relevant experimental measurements and the estimates of physiological, biochemical, and physicochemical parameters for the model, literature reviews were conducted. The focus was placed on oral exposure and modeling carbofuran metabolism in the liver to 16 known metabolites, the enterohepatic circulation of glucuronide conjugates, and the excretion to urine and feces. Cholinesterase inhibition by carbofuran and 3-hydroxycarbofuran is modeled in the bloodand brain. |
| Supplementary Notes |
See also PB2006-114712. |
| Availability Notes |
Available in color paper copy and on CD-ROM only. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Highlights Notes |
%AUT:C. C. /Dary |
| Category Codes |
57U |
| NTIS Prices |
PC A12 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
005100220 |
| Origin |
NTIS |
| Type |
CAT |
