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OLS Field Name OLS Field Data
Main Title The U.S. Environmental Protection Agency's strategic plan for evaluating the toxicity of chemicals.
Author M. Firestone ; R. Kavlock ; H. Zenick
CORP Author Environmental Protection Agency, Washington, DC.
Publisher Office of the Science Advisor, Science Policy Council, U.S. Environmental Protection Agency,
Year Published 2009
Report Number EPA 100/K-09/001
Stock Number PB2010-112389
OCLC Number 352789860
Subjects Chemicals--Research--United States. ; Toxicology. ; Toxicity testing--United States--Methodology. ; Hazardous Substances--toxicity. ; Environmental Exposure. ; Toxicity Tests--methods. ; United States Government Agencies. ; Toxicity testing--Methodology.
Additional Subjects United States.--Environmental Protection Agency--Rules and practice. ; Stragetic plans ; Toxicity ; Chemicals ; Regulatory applications ; Regulatory impacts ; Toxicity pathways ; Chemical screening ; Risk assessments ; Institutional transitions ; Toxic substances ; Hazardous materials ; Toxicity pathway-based risk assessments
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  EPA 100/K-09/001 Region 1 Library/Boston,MA 11/23/2009
EJBD ARCHIVE EPA 100-K-09-001 Headquarters Library/Washington,DC 05/16/2011
EJBD  EPA 100-K-09-001 Headquarters Library/Washington,DC 03/21/2013
EKBD  EPA-100/K-09-001 Research Triangle Park Library/RTP, NC 06/02/2009
ELBD RPS EPA 100 K-09-001 repository copy AWBERC Library/Cincinnati,OH 05/21/2019
EMAD  EPA 100/K-09/001 Region 6 Library/Dallas,TX 09/30/2009 DISPERSAL
ERAD  EPA 100/K-09-001 Region 9 Library/San Francisco,CA 01/28/2013
NTIS  PB2010-112389 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/21/2011
Collation vii, 27 pages : illustrations (some color) ; 28 cm
Abstract To fulfill its mission to protect human health and the environment, EPA must evaluate the risks of adverse health effects resulting from exposure to chemicals in the environment. The traditional risk assessment approach relies heavily on data generated through the intentional dosing of experimental animals. While this approach has provided EPA with sound science to support regulatory decision making over the past several decades, EPA must address ever-increasing demands, including consideration of complex issues such as cumulative exposures, life-stage vulnerabilities, and genetic susceptibilities, not to mention the increasing number of chemicals and cost of toxicity testing. A new approach is proposed to address these demands, an approach based on the application of advances in molecular biology and computational sciences to transform toxicity testing and risk assessment practices. EPA recently took the lead in commissioning the National Research Council (NRC) of the National Academies to develop a long-range vision for toxicity testing and risk assessment. Their 2007 report, Toxicity Testing in the 21st Century: a Vision and a Strategy, envisions a landmark transformation that focuses on identifying and evaluating 'toxicity pathways,' i.e., cellular response pathways responsible for adverse health effects when sufficiently perturbed by environmental agents under realistic exposure conditions. To build upon the transformative changes advocated in the NRC document, while ensuring an internally coordinated and integrated approach, EPA established a cross-Agency workgroup under the auspices of its internal Science Policy Council. This workgroup produced this report that provides a framework for EPA to comprehensively move forward to incorporate this new scientific paradigm into future toxicity testing and risk assessment practices.
Notes "March 2009." "EPA 100/K-09/001." Includes bibliographical references.
Place Published Washington, DC
Availability Notes Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5301 Shawnee Road, Alexandria, VA, 22312, USA.
Corporate Au Added Ent Science Policy Council (U.S.)
PUB Date Free Form 2009
Category Codes 57Y; 99; 91A; 43F
NTIS Prices PC A04
BIB Level m
Medium unmediated
Content text
Carrier volume
Cataloging Source OCLC/T
LCCN 2009416278
Control Number 128600240
OCLC Time Stamp 20190215063034
Language eng
SUDOCS Number EP 1.2:T 66/22
Origin OCLC
OCLC Rec Leader 02506cam 2200637 a 45010