||Factors Associated with Reduced Fertility and Implantation Rates in Females Mated to Acrylamide Treated Rats.
Sublet, V. H. ;
Zenick, H. ;
Smith, M. K. ;
||Health Effects Research Lab., Cincinnati, OH. ;Cincinnati Univ., OH. Dept. of Environmental Health.
Germ cells ;
Dose rate ;
Animal sex behavior ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||A series of studies was conducted to examine the role of copulatory dysfunction, spermatotoxicity, and/or impaired fertilization in the reduced rates of fertility and implantation observed in females mated to acrylamide-treated male rats. In initial experiments, males were gavaged with 0, 5, 15, 30, 45, or 60 mg/kg acrylamide (ACR) for 5 days and then mated serially to naive females. ACR treatment reduced fertility and increased pre- and post-implantation loss, primarily over the first 3 weeks post-treatment. The data suggest that events critical to the fertilizing ability of the sperm appear to play a major role in the reduced reproductive competence associated with ACR treatment in male rats. (Copyright (c) 1989 Elsevier Scientific Publishers Ireland Ltd.)
||Pub. in Toxicology, v55 p53-67 Mar 89. Prepared in cooperation with Cincinnati Univ., OH. Dept. of Environmental Health.
|NTIS Title Notes
||Reprint: Factors Associated with Reduced Fertility and Implantation Rates in Females Mated to Acrylamide Treated Rats.
||PC A03/MF A01