Main Title |
Studies of Echovirus-12 in Volunteers: Determination of Minimal Infectious Dose and the Effect of Previous Infection on Infectious Dose. |
Author |
Schiff, G. M. ;
Stefanovic, G. M. ;
Young, E. C. ;
Sander, D. S. ;
Pennekamp, J. K. ;
|
CORP Author |
Christ Hospital, Cincinnati, OH. Inst. of Medical Research.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1984 |
Report Number |
EPA-R-806173; EPA/600/J-84/298; |
Stock Number |
PB85-203115 |
Additional Subjects |
Viruses ;
Dosage ;
Reprints ;
Echoviruses
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-203115 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
A two-part study of echovirus-12 was done in volunteers. In the first part the human infectious dose of the virus was determined in 149 healthy adults with undetectable serum antibody, each of whom drank 0-330,000 plaque-forming units (pfu) of virus in 100 ml of nonchlorinated water. Infection was defined as fecal shedding of virus or significant (fourfold or greater) increases in serum antibody titer. The HID(50) (i.e., the dose required for infection of 50% of the volunteers) was 919 pfu. Through statistical analysis of the data by probit transformation, a 1% human-infectious dose of 17 pfu was predicted. |
Availability Notes |
Pub. in Jnl. of Infectious Diseases, v150 n6 p858-866 Dec 84. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Studies of Echovirus-12 in Volunteers: Determination of Minimal Infectious Dose and the Effect of Previous Infection on Infectious Dose. |
PUB Date Free Form |
c1984 |
Category Codes |
6M; 6E; 57K; 57U |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
521422354 |
Origin |
NTIS |
Type |
CAT |