| Main Title |
Carcinogenicity and Pesticides: Biological Issues in Extrapolation. |
| Author |
Yang, R. S. H. ;
Huff, J. ;
Germolec, D. R. ;
Luster, M. I. ;
Simmons, J. E. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;National Toxicology Program, Research Triangle Park, NC. ;PATHCO, Inc., Research Triangle Park, NC. |
| Publisher |
1989 |
| Year Published |
1989 |
| Report Number |
EPA/600/D-89/158; |
| Stock Number |
PB90-119215 |
| Additional Subjects |
Pesticides ;
Exposure ;
Carcinogenicity tests ;
Toxic substances ;
Risk assessment ;
Species specificity ;
Dose response relationships ;
Pharmacokinetics ;
Synergism ;
Lethal doses ;
Sex factors
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-119215 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
39p |
| Abstract |
Approximately 41% (26/63) of the pesticides evaluated in the chronic toxicity and carcinogenicity studies of the National Toxicology Program (NTP) showed varying degrees of carcinogenicity. Since those chemicals nominated to the NTP for carcinogenicity studies usually represent a sampling of potentially 'problem' chemicals, this ratio does not implicate the actual percentage of carcinogenic chemicals among all pesticides. In general, results from epidemiological studies are of limited value in prevention and have been done on few pesticides. To assess potential risks of chemicals to humans, extrapolation of the findings in laboratory animals to possible health effects in humans is inevitable. Several important biological issues must be considered in such a process; these include extrapolation between doses, species (including strain and sex), routes of administration and exposure regimens (e.g., intermittent vs.constant rate). Any imperfection in such a process (e.g., hazard identification and risk assessment of any given chemical or other agent) must be taken into consideration during extrapolation. |
| Supplementary Notes |
Prepared in cooperation with National Toxicology Program, Research Triangle Park, NC., and PATHCO, Inc., Research Triangle Park, NC. |
| Category Codes |
68E; 57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
935223437 |
| Origin |
NTIS |
| Type |
CAT |
