| Main Title |
Thermoregulation in Mice Following Acute Administration of Lead Acetate. |
| Author |
Gordon, C. J. ;
Workman, R. A. ;
Highfill, J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/223; |
| Stock Number |
PB88-171087 |
| Additional Subjects |
Toxicology ;
Thermoregulation ;
Lead acetate ;
Mice ;
Laboratory animals ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-171087 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
Several reports in the literature suggest a relationship between lead intoxication and thermoregulatory capacity. To investigate the effects of lead on the control of body temperature, mice of the BALB/c strain were injected intraperitoneally with lead acetate (0 to 100 mg/kg) while colonic temperature was measured 30, 60, and 90 min post-injection at ambient temperatures (Ta) of 20 and 30 C. Lead acetate caused a transient hypothermia, an effect which was augmented at cooler Ta's. In a second experiment, mice were injected with 100 mg/kg lead acetate and placed in a longitudinal temperature gradient to measure their preferred Ta. Lead acetate significantly reduced the preferred Ta during the first 30 min post-injection. Thus, lead acetate-treated mice selected a cooler Ta which augmented the lead-induced hypothermia. In a third experiment it was found that lead acetate-induced lethality was potentiated with increasing Ta. Hence, the hypothermic response to acute lead acetate treatment may be beneficial to survival. |
| Supplementary Notes |
Pub. in Neurotoxicology and Teratology, v9 p193-196 1987. See also PB86-175429. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Thermoregulation in Mice Following Acute Administration of Lead Acetate. |
| PUB Date Free Form |
c1987 |
| Category Codes |
57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
811327569 |
| Origin |
NTIS |
| Type |
CAT |
