Main Title |
Comparative Immunosuppression of Various Glycol Ethers Orally Administered to Fisher 344 Rats. |
Author |
Smialowicz, R. J. ;
Williams, W. C. ;
Riddle, M. M. ;
Andrews, D. L. ;
Luebke, R. W. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA/600/J-92/230; |
Stock Number |
PB92-195833 |
Additional Subjects |
Toxicology ;
Immunosuppression ;
Antibody formation ;
Lipopolysaccharides ;
Rats ;
Alcohol dehydrogenase ;
Enzyme inhibitors ;
Ethylene glycol ;
Reprints ;
Glycol ethers ;
4-methylpyrazole
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-195833 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Oral dosing of adult male F344 rats with the glycol ether 2-methoxyethanol (ME) or its principal metabolite 2-methoxyacetic acid (MAA) results in the suppression of the primary plaque-forming cell (PFC) response to trinitrophenyl-lipopolysaccharide (TNP-LPS). In the present study, the PFC response to TNP-LPS was used to evaluate the immunotoxic potential of ethylene glycol (EG) as well as the glycol ethers 2-methoxyethyl acetate (MEA), 2-(2-methoxyethoxy) ethanol, bis(2-methoxyethyl) ether, 2-ethoxyethanol and its principal metabolite 2-ethoxyacetic acid, 2-ethoxyethyl acetate, and 2-butoxyethanol relative to ME and MAA. Rats were immunized with TNP-LPS and then exposed 4 and 28 hr later to 50, 100, 200, or 400 mg/kg of glycol ether or EG. Three days following immunization, the PFC response to TNP-LPS was determined. In addition to ME and MAA, only MEA, which was as effective as ME, suppressed the PFC response to TNP-LPS. Concomitant administration of the alcohol dehydrogenase inhibitor 4-methylpyrazole with ME or MEA prevented suppression of the PFC response by these glycol ethers. (Copyright (c) 1992 by the Society of Toxicology.) |
Supplementary Notes |
Pub. in Fundamental and Applied Toxicology 18, n4 p621-627 May 92. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Comparative Immunosuppression of Various Glycol Ethers Orally Administered to Fisher 344 Rats. |
Category Codes |
57Y; 57J |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
221932933 |
Origin |
NTIS |
Type |
CAT |