| Main Title |
Toxicology of 1,1,2-Trichloroethane in the Mouse. |
| Author |
White, K. L. ;
Sanders, V. M. ;
Barnes, D. W. ;
Shopp, G. M. ;
Munson, A. E. ;
|
| CORP Author |
Medical Coll. of Virginia, Richmond. Dept. of Pharmacology and Toxicology. ;East Carolina Univ., Greenville, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1985 |
| Report Number |
EPA-R-806481; EPA/600/J-85/415; |
| Stock Number |
PB86-214855 |
| Additional Subjects |
Toxicology ;
Bioassay ;
Mice ;
Laboratory animals ;
Lethal dosage ;
Liver ;
Reprints ;
Ethane/trichloro
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-214855 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
25p |
| Abstract |
1,1,2-Trichloroethane (TCE) was administered to male and female CD-1 mice to evaluate its effect on standard toxicological parameters. Following determination of the acute LD50 (378 mg/kg in males and 491 mg/kg in females), and a 14-day range-finding study, a 90-day drinking water study was performed in which the doses consumed were 4.4, 46, and 305 mg/kg for males and 3.9, 44, and 384 mg/kg for females. The liver was a target of TCE toxicity in both sexes as demonstrated by dose-dependent alterations in hepatic microsomal enzyme activities and serum enzyme levels. The erythroid element of the female mice was also affected, as indicated by significantly decreased hematocrit and hemoglobin levels. |
| Supplementary Notes |
Pub. in Drug and Chemical Toxicology, v8 n5 p333-355 Oct 85. Prepared in cooperation with East Carolina Univ., Greenville, NC. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Toxicology of 1,1,2-Trichloroethane in the Mouse. |
| PUB Date Free Form |
c1985 |
| Category Codes |
6T; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
624112921 |
| Origin |
NTIS |
| Type |
CAT |
