| Main Title |
Effects of Subchronic Fourteen Day Exposure to Beneophyrene in B6C3F1 Female Mice on Host Resistance with Cover Letter 04/15/85. |
| Author |
Munson, A. E. ;
White, K. L. ;
Lysy, H. H. ;
|
| CORP Author |
Medical Coll. of Virginia, Richmond. Dept. of Pharmacology and Toxicology.;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
Apr 1985 |
| Year Published |
1985 |
| Report Number |
FYI-AX-0485-0220-SU; |
| Stock Number |
OTS-0000220-2 |
| Additional Subjects |
Mice ;
Toxicology ;
Organisms ;
Tumors ;
Benzopyrene ;
B6C3F1 female mice ;
Host resistance
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000220-2 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
163p |
| Abstract |
A subcutaneous study was conducted with female B6C3F1 mice injected subcutaneously with 0, 5, 20 or 40 mg/kg benzo(a)pyrene (BaP) in corn oil vehicle daily for 14 days and then challenged with organisms or tumor cells at 4 challenge levels/BaP dose level. Subchronic exposure to BaP resulted in BaP dose-dependent increase in protection to Listeria monocytogenes infection. Exposure to BaP caused a dose-dependent increase in the pulmonary tumor burden of mice administered B16F10 melanoma cells intravenously 1 day after the last BaP exposure. Exposure to BaP caused a decrease in resistance to Herpes Simplex Type 2 virus (not dose-dependent) and Streptococcus pneumonia (dose-dependent). There was no effect observed due to exposure to BaP on the level of protection to Influenza A2. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
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| Category Codes |
57Y |
| NTIS Prices |
PC A09/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010000030 |
| Origin |
NTIS |
| Type |
CAT |
