| Main Title |
Immunotoxicological Investigations in the Mouse: General Approach and Methods. |
| Author |
White, K. L. ;
Sanders, V. M. ;
Barnes, D. W. ;
Shopp, G. M. ;
Munson, A. E. ;
|
| CORP Author |
Medical Coll. of Virginia, Richmond. Dept. of Pharmacology and Toxicology. ;East Carolina Univ., Greenville, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1985 |
| Report Number |
EPA-R-806481; EPA/600/J-85/414; |
| Stock Number |
PB86-209061 |
| Additional Subjects |
Toxicology ;
Immunology ;
Mice ;
Laboratory animals ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-209061 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
34p |
| Abstract |
The adverse effects of chemicals on the lymphoreticular system have generated considerable toxicological interest. In the series of papers, the effects of selected environmentally relevant compounds are reported. The first paper describes the methods and general approach used in judging a chemical's potential risk to the immune system. Risk evaluation was approached utilizing acute, 14- and 90-day studies. Both sexes of the CD-1 random-bred mouse were employed. The immune system was evaluated against a background of more standard toxicological parameters, which included fluid consumption, body and organ weights, hematology, serum and liver chemistries, hepatic microsomal enzyme activities and blood coagulation. Bone marrow status was evaluated by assessing DNA synthesis. |
| Supplementary Notes |
Pub. in Drug and Chemical Toxicology 8, n5 p299-331 Oct 85. Prepared in cooperation with East Carolina Univ., Greenville, NC. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Immunotoxicological Investigations in the Mouse: General Approach and Methods. |
| PUB Date Free Form |
c1985 |
| Category Codes |
6T; 57Y; 57J |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
622718683 |
| Origin |
NTIS |
| Type |
CAT |
