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RECORD NUMBER: 25 OF 27

OLS Field Name OLS Field Data
Main Title Use of Prolonged Treatment and the Fluctuation Test to Detect Mutations in Human Fibroblasts Treated with Methyl Methanesulfonate.
Author Huang, Shiu L. ; Biddix, Gwyn ; Waters, Michael D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-600/J-82-302;
Stock Number PB83-189563
Additional Subjects Toxicology ; Humans ; Reprints ; Methyl methanesulfonate ; Fibroblasts ; Mutagenesis ; Fluctuation test
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB83-189563 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 10p
Abstract The methyl methanesulfonate (MMS) induction of 6-thioguanine-resistant (6TG) mutants in non-synchronized human fibroblasts has been quantitatively characterized. A 24-h MMS treated failure to induce mutations in non-synchronized cultures. However, exposure of growing cells to MMS for 3 days caused a significant increase in the mutation frequencies. The mutations induction was dose-dependent. The fluctuation test was also useful in detecting the mutagenic activity of MMS in human fibroblasts. Prolonged treatment of cultures made the human cell mutagenesis testing system more sensitive.
Supplementary Notes Pub. in Mutation Research 105, p175-182 1982. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Use of Prolonged Treatment and the Fluctuation Test to Detect Mutations in Human Fibroblasts Treated with Methyl Methanesulfonate.
PUB Date Free Form 8 Jun 82
Category Codes 6T; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 320323388
Origin NTIS
Type CAT