||Concept of Activity Profiles of Antimutagens.
Waters, M. D. ;
Brady, A. L. ;
Stack, H. F. ;
Brockman, H. E. ;
||Environmental Protection Agency, Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Illinois State Univ., Normal. Dept. of Biological Sciences.
||1 Aug 89
Free radicals ;
Salmonella typhimurium ;
Mutagenicity tests ;
Carcinogenicity tests ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The paper will consider the use of short-term bioassays to identify antimutagenic and anticarcinogenic substances and to classify them according to the locus of their protective influence, i.e., intracellular or extracellular, and putative mechanism(s) of action. In the extracellular environment, inhibition of formation or uptake of mutagens and inactivation of promutagenic or mutagenic species are examples of antimutagenic mechanisms. Intracellularly, antimutagenic substances have been described as 'scavengers' of radicals, 'blocking agents' (involving at least 3 different mechanisms), and 'suppressing agents'. Additional intracellular mechanisms include alterations in DNA repair processes and/or modification of the genotoxic response to the mutagen/carcinogen. The presentation format will be based on the genetic activity profile (GAP) methodology developed by the authors. The GAPs of known mutagens/carcinogens will be presented together with newly designed profiles for antimutagens/anticarcinogens according to the classification scheme outlined above.
||Pub. in Antimutagenesis and Anticarcinogenesis Mechanisms II, p87-104 Jan 90. See also PB90-112806. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC., and Illinois State Univ., Normal. Dept. of Biological Sciences.
||Reprint: Concept of Activity Profiles of Antimutagens.
||PC A03/MF A01