Main Title |
Effects of Trimethyltin on Dopaminergic and Serotonergic Function in the Central Nervous System. |
Author |
DeHaven, D. L. ;
Walsh, T. J. ;
Mailman, R.B. ;
|
CORP Author |
North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1984 |
Report Number |
EPA-R-809644; EPA/600/J-84/328; |
Stock Number |
PB86-117231 |
Additional Subjects |
Central nervous system ;
Toxicology ;
Brain ;
Dopamine ;
Serotonin ;
Rats ;
Laboratory animals ;
Reprints ;
Tin/trimethyl ;
Metabolites
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-117231 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
The effects of trimethyltin (TMT) administration on regional concentrations of dopamine (DA), serotonin (5-HT), and their metabolites were determined. Acute administration of 3 or 7 mg/kg TMT (as the chloride) to adult male Long-Evans rats caused alterations in both dopaminergic and serotonergic function in brain at 7 days posttreatment. Dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were decreased in the nucleus accumbens of rats treated with 7 mg/kg, with a trend occurring with the 3-mg/kg dose group. Conversely, concentrations of DA or DOPAC were not altered in striatum, olfactory tubercle, septum, or amygdala/pyriform cortex. Administration of 3 mg/kg TMT decreased the concentration of serotonin in striatum and nucleus accumbens, and increased the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in hippocampus. The 7-mg/kg dose resulted in increased concentrations of 5-HIAA in striatum, nucleus accumbens, septum, amygdala/pyriform cortex, and hippocampus, and also decreased the concentration of 5-HT only in amygdala/pyriform cortex. |
Supplementary Notes |
Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
Availability Notes |
Pub. in Toxicology and Applied Pharmacology 75, p182-189 1984. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effects of Trimethyltin on Dopaminergic and Serotonergic Function in the Central Nervous System. |
PUB Date Free Form |
c1984 |
Category Codes |
6T; 57Y |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
601716439 |
Origin |
NTIS |
Type |
CAT |