Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 39 OF 113

OLS Field Name OLS Field Data
Main Title Exocrine Pancreatic Neoplasms Induced by Methylazoxymethanol Acetate in the Guppy 'Poecilia reticulata'.
Author Fournie, J. W. ; Hawkins, W. E. ; Overstreet, R. M. ; Walker, W. W. ;
CORP Author Environmental Research Lab., Gulf Breeze, FL. ;Gulf Coast Research Lab., Ocean Springs, MS.;National Cancer Inst., Bethesda, MD. Div. of Cancer Etiology.;Army Medical Research and Development Command, Washington, DC.
Year Published 1987
Report Number EPA/600/J-87/309; N01-CP-2-6008;
Stock Number PB88-196266
Additional Subjects Organic compounds ; Pancreatic neoplasms ; Fresh water fishes ; Water pollution ; Carcinogens ; Exposure ; Histology ; Sampling ; Malignant neoplasms ; Humans ; Laboratory animals ; Adenoma ; Adenocarcinomas ; Cells(Biology) ; Tests ; Cytoplasm ; Photomicrographs ; Reprints ; Methylazoxymethanol acetate ; MAM-Ac ; Poecilla reticulata ; Guppy
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB88-196266 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/04/1988
Collation 13p
Abstract Exocrine pancreatic neoplasms developed in the guppy Poecillia reticulata following a single brief exposure to methylazoxymethanol acetate. Fish 6-10 days old were exposed to concentrations of MAM-Ac up to 100 mg/liter for 2 hours. Exposed specimens were transferred to carcinogen-free water and sampled periodically for tumor development. Pancreatic neoplasms occurred in approximately 9% of histologically examined individuals exposed to 10 mg MAM-Ac/liter or less. Neoplastic lesions were not found in 122 control specimens. The neoplasms included 6 cases diagnosed as adenoma, 7 cases diagnosed as acinar cell carcinoma, and 2 cases diagnosed as adenocarcinoma. The findings of carcinogen-induced pancreatic neoplasms in guppies further strengthen the usefulness of small fish species in carcinogen testing.
Supplementary Notes Pub. in Jnl. of the National Cancer Institute, v78 n4 p715-725 Apr 87. Prepared in cooperation with Gulf Coast Research Lab., Ocean Springs, MS. Sponsored by National Cancer Inst., Bethesda, MD. Div. of Cancer Etiology, and Army Medical Research and Development Command, Washington, DC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Exocrine Pancreatic Neoplasms Induced by Methylazoxymethanol Acetate in the Guppy 'Poecilia reticulata'.
PUB Date Free Form c1987
Category Codes 68D; 57; 57Z
NTIS Prices PC A03/MF A01
Primary Description 600/04
Document Type NT
Cataloging Source NTIS/MT
Control Number 817624619
Origin NTIS
Type CAT