| Main Title |
Toxicity of Acetylenic Alcohols to the Fathead Minnow, 'Pimephales promelas': Narcosis and Proelectrophile Activation. |
| Author |
Veith, G. D. ;
Lopnick, R. L. ;
Russom, C. L. ;
|
| CORP Author |
Environmental Research Lab.-Duluth, MN. |
| Publisher |
c1989 |
| Year Published |
1989 |
| Report Number |
EPA/600/J-89/084; |
| Stock Number |
PB90-103672 |
| Additional Subjects |
Fishes ;
Alcohols ;
Toxicity ;
Narcosis ;
Electrophilic reactions ;
Reprints ;
Water pollution effects(Animals) ;
Pimephales promelas ;
Propargylic alcohols ;
Homopropargylic alcohols ;
Structure-activity relationship
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-103672 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
The 96-h LC50 values for 16 acetylenic alcohols in the fathead minnow (Pimephales promelas) were determined using continuous-flow diluters. The measured LC50 values for seven tertiary propargylic alcohols agreed closely with the QSAR predictions based upon data for other organic non-electrolytes acting by a narcosis mechanism. Four primary and four secondary propargylic alcohols were 7 to 4600 times more toxic than the respective narcotic toxicity estimated by QSAR. Metabolic activation to electrophilic alpha, beta-unsaturated propargylic aldehydes or ketones is proposed to account for the increased toxicity. 3-Butyn-1-ol and 4-pentyn-2-ol, primary and secondary homopropargylic alcohols, were 320 and 160, respectively, times more toxic than predicted. In this case an activation step involving biotransformation to an allenic electrophile intermediate was proposed. (Copyright (c) 1989 Taylor and Francis, Ltd.) |
| Supplementary Notes |
Pub. in Xenobiotica, v19 n5 p555-565 1989. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Toxicity of Acetylenic Alcohols to the Fathead Minnow, 'Pimephales promelas': Narcosis and Proelectrophile Activation. |
| Category Codes |
57Y; 68D; 48G |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
932617090 |
| Origin |
NTIS |
| Type |
CAT |
