Main Title |
Developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose--response modeling for estimation of benchmark doses |
Author |
Rogers, John H. ;
Rogers, J. M. ;
Mole, M. L. ;
Chernoff, N. ;
Barbee, B. D. ;
Turner., C. I.
|
Other Authors |
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
Publisher |
Environmental Protection Agency, |
Year Published |
1993 |
Report Number |
EPA/600/J-94/209 |
Stock Number |
PB94-163888 |
OCLC Number |
47170737 |
Subjects |
Methanol as fuel--toxicity
|
Additional Subjects |
Teratogenic compounds ;
Methanol ;
Toxicity ;
Dose-response relationships ;
Congenital abnormalities ;
Cleft palate ;
Oral administration ;
Blood ;
Reprint ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
ELCD |
EPA 600-J-94-209 |
|
NVFEL Library/Ann Arbor, MI |
09/09/2011 |
STATUS |
NTIS |
PB94-163888 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
var. pagings 28 cm. |
Abstract |
Pregnant CD-1 mice were exposed to 1,000, 2,000, 5,000, 7,500, 10,000, or 15,000 ppm on methanol for 7 hr/day on days 6-15 of gestation. On day 17 of gestation, remaining mice were weighed, killed and the gravid uterus was removed. Numbers of implantation sites, live and dead fetuses and resorptions were counted, and fetuses were examined externally and weighed as a litter. Significant increases in the incidence of exencephaly and cleft palate were observed at 5,000 ppm and above, increased postimplantation mortality at 7,500 ppm and above (including an increasing incidence of full-litter resorption), and reduced fetal weight at 10,000 ppm and above. A dose-related increase in cervical ribs or ossification sites lateral to the seventh cervical vertebra was significant at 2,000 ppm and above. Thus, the NOAEL for the developmental toxicity in this study is 1,000 ppm. The results of this study indicate that inhaled methanol is developmentally toxic in the mouse at exposure levels which were not maternally toxic. Litters of pregnant mice gavaged orally with 4 g methanol/kg displayed developmental toxic effects similar to those seen in the 10,000 ppm methanol exposure group. (Copyright (c) 1993 Wiley-Liss, Inc.) |
Notes |
"EPA/600/J-94/209." Includes bibliographic references. Caption title. |
Place Published |
Triangle Park, NC : |
Supplementary Notes |
Pub. in Teratology, v47 n3 p175-188 Mar 93. See also PB93-106979. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
PUB Date Free Form |
1993. |
BIB Level |
m |
Cataloging Source |
OCLC/T |
OCLC Time Stamp |
20010621121152 |
Language |
eng |
Origin |
OCLC |
Type |
MERGE |
OCLC Rec Leader |
01020nam 2200277Ia 45020 |