Main Title |
Cyclopenta-Fused Isomers of Benz(a)Anthracene II: Mutagenic Effects on Mammalian Cells. |
Author |
Nesnow, W. ;
Leavitt, S. ;
Easterling, R. ;
McNair, P. ;
Toney, G. E. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. School of Public Health. |
Year Published |
1984 |
Report Number |
EPA-600/D-84-071; |
Stock Number |
PB84-168772 |
Additional Subjects |
Benzanthracenes ;
Toxicology ;
Cells(Biology) ;
Aromatic polycyclic hydrocarbons ;
Metabolism ;
Mutagenesis ;
Benzanthracene ;
Benzaceanthrylenes
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-168772 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15p |
Abstract |
Cyclopenta-fused polycyclic aromatic hydrocarbons (PAH) are a unique class of PAH found in the environment. Acenaphthylene, acephenanthrylene and cyclopenta (cd) pyrene represent characterized cyclopenta-PAH already identified as air pollutants. The pyrolytic synthesis of PAH from two carbon fragments (3) suggests that many more such cyclopenta-ring fusions are possible and may be characterized from environmental samples. Cyclopenta-PAH are non-alternate PAH in which the fused five membered ring provides a new site for metabolic attack by the cytochrome P-450 mixed-function oxidases. The study of the metabolism, metabolic activation and mutagenesis of these chemicals allows a probe into the mechanism of oxygen transfer and the stereo-and regio-specificity of the cytochrome P-450 mixed-function oxidases as well as an understanding of the competition between sites of metabolic action by these enzymes. This chapter is a preliminary report of metabolism and mutagenesis studies with four cyclopenta-fused isomers of benz(a)anthracene: benz(j)aceanthrylene, BjA; benz(e)aceanthrylene, BeA; benz(1)aceanthrylene, B1A; and benz(k)acephenanthrylene, BkA. |
Supplementary Notes |
Prepared in cooperation with North Carolina Univ. at Chapel Hill. School of Public Health. |
PUB Date Free Form |
1984 |
Category Codes |
6T; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
414624330 |
Origin |
NTIS |
Type |
CAT |