| Main Title |
Trimmed Spearman-Karber Method for Estimating Median Lethal Concentrations in Toxicity Bioassays. |
| Author |
Hamilton, Martin A. ;
Russo, Rosemarie C. ;
Thurston, Robert V. ;
|
| CORP Author |
Montana State Univ., Bozeman. Fisheries Bioassay Lab.;Environmental Research Lab., Duluth, MN. |
| Year Published |
1977 |
| Report Number |
EPA-R-800861; EPA-600/J-77-178; |
| Stock Number |
PB81-191918 |
| Additional Subjects |
Toxicology ;
Bioassays ;
Lethal dosage ;
Concentration(Composition) ;
Estimating ;
Reprints ;
Toxic substances
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB81-191918 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Several methods for treatment of data from toxicity tests to determine the median lethal concentration (LC50) are discussed. The probit and logit models widely used for these calculations have deficiencies; therefore, a calculational method, named the 'trimmed Spearman-Karber method', is developed. Examples of actual and hypothetical bioassay test data are given, and comparisons are made of the abilities of these three methods to treat these data. The trimmed Spearman-Karber method is not subject to the problems of the probit and logit models, has good statistical properties, is easy to use, and is recommended for accurate and precise calculation of LC50 values and their 95% confidence interval end points. |
| Supplementary Notes |
Pub. in Environmental Science and Technology, v11 n7 p714-719 1977. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Trimmed Spearman-Karber Method for Estimating Median Lethal Concentrations in Toxicity Bioassays. |
| PUB Date Free Form |
c1977 |
| Category Codes |
6T; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323797094 |
| Origin |
NTIS |
| Type |
CAT |
