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Main Title Approach to Using Toxicogenomic Data in U.S. EPA Human Health Risk Assessments: A Dibutyl Phthalate Case Study.
Author S. Euling ; I. Androulakis ; B. Benson ; W. Chiu ; P. Foster
Other Authors
Author Title of a Work
K. Gaido
L. E. Gray
S. Hester
C. Keshava
S. Makris
M. Ovacik
C. Thompson
L. White
V. Wilson
CORP Author Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.; University of Medicine and Dentistry of New Jersey, Newark.; National Inst. of Environmental Health Sciences, Research Triangle Park, NC.; Food and Drug Administration, Rockville, MD.
Year Published 2009
Report Number EPA/600/R-09-028F
Stock Number PB2010-109287
Additional Subjects Toxicity ; Genomics ; Phthalates ; Human health ; Risk assessment ; Chemical assessments ; Genes ; Environmental exposure pathway ; Environmental effects ; Research needs ; Case studies ; Recommendations ; Dibutyl phthalate (DBP)
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB2010-109287 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 240p
Abstract We developed a systematic approach for evaluating and utilizing toxicogenomic data in health assessment. This report describes this approach and a case study conducted for dibutyl phthalate (DBP) to illustrate the approach. As a result of the case-study exercise, we refined the initial case-study approach for general use in new chemical assessments. In this report, we reviewed some of the recent and ongoing activities regarding the use of genomic data in risk assessment, inside and outside of the U.S. Environmental Protection Agency (EPA). We also identified research needs, recommendations, and issues for future consideration when using genomic data in risk assessments. Toxicogenomics is the application of genomic technologies (e.g., transcriptomics, proteomics, metabolomics, genome sequence analysis) to study the effects of environmental chemicals on human health and the environment.
Supplementary Notes Prepared in cooperation with University of Medicine and Dentistry of New Jersey, Newark., National Inst. of Environmental Health Sciences, Research Triangle Park, NC. and Food and Drug Administration, Rockville, MD.
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PUB Date Free Form Sep 2009
Category Codes 57Y; 57F; 57U; 68G
NTIS Prices PC A12
Document Type NT
Cataloging Source NTIS/MT
Control Number 118302250
Origin NTIS
Type CAT