||Approach to Using Toxicogenomic Data in U.S. EPA Human Health Risk Assessments: A Dibutyl Phthalate Case Study.
S. Euling ;
I. Androulakis ;
B. Benson ;
W. Chiu ;
||Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.; University of Medicine and Dentistry of New Jersey, Newark.; National Inst. of Environmental Health Sciences, Research Triangle Park, NC.; Food and Drug Administration, Rockville, MD.
Human health ;
Risk assessment ;
Chemical assessments ;
Environmental exposure pathway ;
Environmental effects ;
Research needs ;
Case studies ;
Dibutyl phthalate (DBP)
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||We developed a systematic approach for evaluating and utilizing toxicogenomic data in health assessment. This report describes this approach and a case study conducted for dibutyl phthalate (DBP) to illustrate the approach. As a result of the case-study exercise, we refined the initial case-study approach for general use in new chemical assessments. In this report, we reviewed some of the recent and ongoing activities regarding the use of genomic data in risk assessment, inside and outside of the U.S. Environmental Protection Agency (EPA). We also identified research needs, recommendations, and issues for future consideration when using genomic data in risk assessments. Toxicogenomics is the application of genomic technologies (e.g., transcriptomics, proteomics, metabolomics, genome sequence analysis) to study the effects of environmental chemicals on human health and the environment.
||Prepared in cooperation with University of Medicine and Dentistry of New Jersey, Newark., National Inst. of Environmental Health Sciences, Research Triangle Park, NC. and Food and Drug Administration, Rockville, MD.
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||57Y; 57F; 57U; 68G