Main Title |
Trimethyltin-Induced Hyperactivity: Time Course and Pattern. |
Author |
Ruppert, Patricia H. ;
Walsh, Thomas J. ;
Reiter, Lawrence W. ;
Dyer, Robert S. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1982 |
Report Number |
EPA-600/J-82-132; |
Stock Number |
PB83-191528 |
Additional Subjects |
Toxicology ;
Rats ;
Laboratory animals ;
Dosage ;
Reprints ;
Tin/chloride-trimethyl ;
Hyperactivity
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB83-191528 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
Adult male Long-Evans rats were intubated with either 0,5,6, or 7 mg/kg trimethyltin chloride. Activity was measured for 1 hr in a figure-eight maze 2 hr after dosing (day 0) and again on days 4,8,16 and 32 after dosing. On days 49-51, activity was measured in a figure-eight maze over a 23-hr period. There were no differences in activity on the day of dosing, but on all subsequent test days the 7 mg/kg TMT animals were hyperactive. TMT also altered the spatial pattern of activity: activity was increased in the 'figure-eight' portion of the maze but not in the blind alleys. Activity of the 7 mg/kg TMT animals was increased during all periods in the 23-hr test. Decreases in the length of the pyramidal cell line (CA1 to CA3c of the hippocampus) confirmed neuronal cell loss in TMT-dosed rats. |
Supplementary Notes |
Pub. in Neurobehavioral Toxicolgy and Teratology, v4 p135-139 1982. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Trimethyltin-Induced Hyperactivity: Time Course and Pattern. |
PUB Date Free Form |
1982 |
Category Codes |
6T; 6E; 57Y; 57O |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
321643646 |
Origin |
NTIS |
Type |
CAT |