| Main Title |
Trimethyltin Impairs Retention of a Passive Avoidance Task. |
| Author |
Walsh, Thomas J. ;
Gallagher, Michela ;
Bostock, Elizabeth ;
Dyer, Robert S. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1982 |
| Report Number |
EPA-600/J-82-308; |
| Stock Number |
PB83-193672 |
| Additional Subjects |
Toxicology ;
Brain ;
Rats ;
Laboratory animals ;
Behavior ;
Reprints ;
Tin/trimethyl ;
Toxic substances ;
Passive avoidance
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-193672 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Trimethyltin is a neurotoxic organometal which produces neuronal damage in several limbic regions including the hippocampus, amygdala and the pyriform cortex. One administration of trimethyltin (5,6 or 7 mg/kg) twenty one days prior to passive avoidance conditioning produced an impairment of retention when animals were tested 24 hours after training. Rats treated with trimethyltin exhibited shorter step-through latencies and freezing durations during the retention test. It was observed that the three dosages of trimethyltin were equally effective in disrupting retention performance. These retention deficits were not secondary to alterations in footshock sensitivity. The data presented here indicate that acute trimethyltin administration disrupted learning and memory. This compound might be a useful tool for examining the role of the limbic system in associative processes. |
| Supplementary Notes |
Pub. in Neurobehavioral Toxicology and Teratology, v4 p163-167 1982. Prepared in cooperation with North Carolina Univ. at Chapel Hill. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Trimethyltin Impairs Retention of a Passive Avoidance Task. |
| PUB Date Free Form |
1982 |
| Category Codes |
6T; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
321645387 |
| Origin |
NTIS |
| Type |
CAT |
