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Main Title Patho-Physiologic Response to Single and Multiple Air Pollutants in Humans and Animals.
Author Cor, Morton ; Kotsk, Nancy ; Stanto, Dolores ; Bel, William ; Thoma, Armand P. ;
CORP Author Pittsburgh Univ., Pa. Graduate School of Public Health.
Year Published 1970
Report Number PH-86-67-73; 0593;
Stock Number PB-195 888
Additional Subjects ( Respiratory diseases ; Air pollution) ; ( Sulfur dioxide ; Respiratory diseases) ; ( Public health ; Air pollution) ; Pathophysiology ; Cats ; Lung ; Sodium chloride ; Air flow ; Nose(Anatomy) ; Pharynx ; Concentration(Composition) ; Aerosols ; Trachea ; Respiration ; Air pollution damage
Library Call Number Additional Info Location Last
NTIS  PB-195 888 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 136p
Abstract Twenty healthy, adult male cats were lightly anesthetized (Nembutal), tracheotomized and were then breathed by a Harvard pump at a fixed frequency and tidal volume. Purified Medical Grade breathing air with or without sulfur dioxide in air or sulfur dioxide in combination with sodium chloride aerosol in air, was delivered to the animals in predetermined exposure sequences and for fixed durations of time. Parameters of response used to judge adaptation of cats to the inhaled challenges of pollutants were pulmonary flow resistance and lung compliance. In addition, pollutant mixtures were delivered to animals via endotracheal catheter and/or face mask to evaluate the possible influence of receptors which may be present in the nasopharyngeal chamber and in the trachea above the tracheal cannula. The major finding was the variability of the responses of the test animals. Certain subjects showed increased pulmonary flow resistance at low SO2 concentration, and were the analogues of the 'reactors' in human populations. Approximately 20 ppm SO2 in air were required to evoke a significant change in pulmonary flow resistance in 'reactors'. The majority of animals showed no response at this concentration of sulfur dioxide in air, either alone or in the presence of NaCl aerosol. When the pollutants were administered via endotracheal catheter and face mask, an increased frequency of significant changes in pulmonary flow resistance in these animals was suggested. All alterations in parameters of response were reversible shortly after exposure ceased. Morphological examination of lung tissue sections after rapid freezing with Freon indicated that measurement of alterations in airway size is not possible in the range of changes of pulmonary flow resistance reported here (< 100%). Methods and data for all experiments are presented in detail.
NTIS Title Notes Final rept. 16 Jan 68-31 May 70.
PUB Date Free Form 1 Jul 70,
Category Codes 6S; 13B; 57W; 57U; 68A
NTIS Prices PC A07 MF A01
Document Type NT
Cataloging Source NTIS/MT
Control Number 326514366
Origin NTIS
Type CAT