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OLS Field Name OLS Field Data
Main Title Use of Carbon Dioxide Challenge to Detect Toxicant - Induced Changes in Cardiopulmonary Function of Awake Rats.
Author Tepper, J. S. ; Wiester, M. J. ; King, M. E. ; Weber, M. F. ; Costa., D. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Toxicology Branch. ;Northrop Services, Inc., Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/550;
Stock Number PB91-116038
Additional Subjects Toxicology ; Carbon dioxide ; Rats ; Reprints ; Heart function tests ; Respiratory function tests ; Air pollution effects(Animals) ; Computer applications ; Wakefulness ; Hemodynamics
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB91-116038 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/04/1991
Collation 19p
Abstract A system has been developed to measure simulatneously the effects of inhaled toxicants on cardiopulmonary function in four awake rats before, during and after exposure. One day prior to testing, Fischer-344 and Sprague-Dawley rats were implanted with an intrapleural or carotid catheter. On the day of testing, the rats were placed into a restraint system to reduce movement artifacts and to keep rats from disturbing the implanted catheters without imposing limitations on functional measurements. The rats were then sealed into constant-volume plethysmographs mounted on the door of a 0.32-cu m Rochester exposure chamber. Thirty minutes after the rats were placed into the plethysmographs, control measurements were obtained. Under the control of a digital computer, the rats were exposed for 15-min periods to 4% CO2. During testing, tidal volume, intrapleural pressure, blood pressure, and the electrocardiogram were recorded on the polygraph, and were digitized and stored in the computer. Four-second breathing epochs were recorded and analyzed, and the results were displayed on line.
Supplementary Notes Inhalation Toxicology, Premier Issue, p79-95, Oct 88. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Use of Carbon Dioxide Challenge to Detect Toxicant - Induced Changes in Cardiopulmonary Function of Awake Rats.
Category Codes 57Y; 57S; 68A
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 101123366
Origin NTIS
Type CAT