| Main Title |
Endpoints of Spermatotoxicity in the Rat After Short Duration Exposures to Fourteen Reproductive Toxicants. |
| Author |
Linder, R. E. ;
Strader, L. F. ;
Slott, V. L. ;
Suarez, J. D. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-93/107; |
| Stock Number |
PB93-175768 |
| Additional Subjects |
Spermatozoa ;
Reproduction(Biology) ;
Toxicology ;
Toxic substances ;
In vivo analysis ;
Structure-activity relationships ;
Sperm motility ;
Pathology ;
Testis ;
Epididymis ;
Tables(Data) ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-175768 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
Multiple endpoints of spermatotoxicity in short in vivo tests were investigated in several chemicals which produce minimal to severe subchronic reproductive effects. Six chemicals (boric acid, dinoseb, 2,5-hexanedione, methoxychlor, metronidazole, ornidazole) produced spermatotoxicity. Chlordimeform was equivocal while pp'-DDT, n-hexane, and sodium chlorite were negative. Chemicals with known acute effects (benomyl, busulfan, EGME, nitrobenzene) elicited expected responses. Testicular histology, sperm head counts, cauda sperm counts, sperm morphology and velocity were the most sensitive endpoints, but histopathology was the most consistent indicator of damage. The data suggested that most chemicals which produce moderate sperm damage are detectable in a short duration test. Multiple endpoints enhanced interpretations, identified cellular targets, and provided insight on mechanisms. The responses often predicted effects seen in subchronic exposures. The short test could be used as a screen in SAR studies or to prioritize further evaluations. As a supplement, the short test could enhance the design and interpretation of longer tests. |
| Supplementary Notes |
Pub. in Reproductive Toxicology, v6 p491-505 Nov 92. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Endpoints of Spermatotoxicity in the Rat After Short Duration Exposures to Fourteen Reproductive Toxicants. |
| Category Codes |
57Y; 57S |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
316130780 |
| Origin |
NTIS |
| Type |
CAT |
