| Main Title |
Effect of Alcohol on Behavioral and Autonomic Thermoregulation in Mice. |
| Author |
Gordon, C. J. ;
Stead, A. G. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1986 |
| Stock Number |
PB88-171111 |
| Additional Subjects |
Toxicology ;
Alcohols ;
Behavior ;
Mice ;
Laboratory animals ;
Reprints ;
Thermoregulation
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-171111 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Male, BALB/c mice were injected intraperitoneally with ethyl alcohol (ethanol) in dosages of 0, 0.03, 0.1, 0.3, 1.0, or 3.0 g/kg and then placed in a temperature gradient which permitted the measurement of preferred ambient temperature (Ta). The 3 g/kg dosage of ethanol resulted in a slight lowering of the preferred Ta during the first 30 min of placement in the gradient. However, there was no overall statistically significant effect of alcohol dosage on preferred Ta. In another experiment, BALB/c mice were treated with the aforementioned thanol dosages while metabolic rate (MR), evaporative water loss (EWL), and colonic temperature were measured 60 min post-injection at Ta's of 20, 30, and 35 C a dosage of 3 g/kg caused a significant decrease in MR, EWL, and colonic temperature. At a Ta of 30 C this same dosage caused significant reduction in colonic temperature, however; at Ta of 35 C ethanol had no effect on these parameters. In spite of the significant decrease in colonic temperature at a Ta of 30 C, which approximates the normal preferred Ta, the behavioral thermal preference was marginally affected. It is not clear whether or not ethanol injection results in a decrease in the set-point body temperature. |
| Supplementary Notes |
Pub. in Alcohol, v3 p339-343 1986. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effect of Alcohol on Behavioral and Autonomic Thermoregulation in Mice. |
| PUB Date Free Form |
1986 |
| Category Codes |
57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
812722835 |
| Origin |
NTIS |
| Type |
CAT |
