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Main Title Genetic Activity Profiles in the Testing and Evaluation of Chemical Mixtures.
Author Waters, M. D. ; Claxton, L. D. ; Stack, H. F. ; Brady, A. L. ; Graedel, T. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;A.T. and T. Bell Labs., Murray Hill, NJ.
Publisher 1990
Year Published 1990
Report Number EPA/600/D-89/209;
Stock Number PB90-129693
Additional Subjects Air pollution ; Toxicity ; Chemical analysis ; Mixtures ; Bioassay ; Detection ; Graphs(Charts) ; Mutagenicity tests ; Carcinogenicity tests ; Toxic substances ; Health hazards ; Dose-response relationships
Library Call Number Additional Info Location Last
NTIS  PB90-129693 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 35p
Abstract Some knowledge of the potential genetic activity of a complex environmental mixture may be gained from an assessment of the genetic activity of its component chemicals. The expanded Genetic Activity Profile (GAP) data base provides a computer-generated graphic representation of genetic bioassay data as a function of dose of the substance tested. In addition, the Atmospheric Chemical Compound (ACC) data base contains information on chemical structures, properties, detection methods and sources of chemicals found in ambient air. Using the combined data bases, information on the quantity of an individual chemical present within a mixture or fraction of a mixture may be related to the quantity (lowest effective dose, LED) of the chemical required to demonstrate a positive response in one or more genetic bioassays. Quantitative information on the carcinogenic potency of each individual compound (TD50 value) may also be related to the quantity present in the mixture or mixture fraction. In turn, the quantity of the chemical in the complex mixture to which humans are exposed may be estimated and used to calculate the percent human exposure dose/rodent potency dose (HERP) for the chemical.
Supplementary Notes Proceedings of the workshop on Experimental and Epidemiologic Applications to Risk Assessment of Complex Mixtures, Espoo, Finland, May 14-17, 1989. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC., and A.T. and T. Bell Labs., Murray Hill, NJ.
Category Codes 57Y; 57F; 68G
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 007528669
Origin NTIS
Type CAT