| Main Title |
Assessment of Teratogenic Potential of Trichlorofon in Mice and Rats (Journal Version). |
| Author |
Courtney, K. D. ;
Andrews, J. E. ;
Springer, J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Food and Drug Administration, Washington, DC. Center for Food Safety and Applied Nutrition. |
| Publisher |
1986 |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/498; |
| Stock Number |
PB89-130421 |
| Additional Subjects |
Insecticides ;
Pesticides ;
Toxicity ;
Teratogens ;
Laboratory animals ;
Concentration(Composition) ;
Exposure ;
Lethal dosage ;
Phosphorus organic compounds ;
Reprints ;
Trichlorofon ;
Phosphoric acid/trichloro-hydroxyethyl-(dimethyl ester)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-130421 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
24p |
| Abstract |
Trichlorofon was evaluated for its teratogenic potential in the CD-1 mouse at doses of 200, 300, or 400 mg/kg/day administered by gavage on days 7-16 of gestation. In the CD-1 mouse, TCF was teratogenic, fetotoxic and lethal at the two highest dose levels which were also maternally lethal. At the lowest dose level which was not maternally lethal, there was a significant decrease in the number of calcified centers in the forepaws and hindpaws indicating fetotoxicity and a delay in maturation. TCF was administered at doses of 50, 100, or 200 mg/kg/day to CD rats by gavage on gestational days 7-19 (study I) or 8-20 (study II). In both study I and II, the highest dose level was maternally lethal. In study I, TCF was teratogenic with a shift in rib profile. In study II, TCF was teratogenic with an increased incidence in malformations of the urinary system. Additionally, TCF was fetotoxic with reduced ossification of the skulls. |
| Supplementary Notes |
Pub. in Jnl. of Environmental Science Health, vB21 n3 p207-227 1986. Prepared in cooperation with Food and Drug Administration, Washington, DC. Center for Food Safety and Applied Nutrition. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Assessment of Teratogenic Potential of Trichlorofon in Mice and Rats (Journal Version). |
| Category Codes |
57P; 57Y; 68E; 68G |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
904115176 |
| Origin |
NTIS |
| Type |
CAT |
