Main Title |
Assay of Chicken Brain Neurotoxic Esterase Activity Using Leptophosoxon as the Selective Neurotoxic Inhibitor. |
Author |
Soliman, Salah A. ;
Curley, August ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
Year Published |
1981 |
Report Number |
EPA-600/J-81-235; |
Stock Number |
PB82-127598 |
Additional Subjects |
Esterases ;
Toxicology ;
Brain ;
Inhibitors ;
Chickens ;
Bioassay ;
Reprints ;
Neurotoxins
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB82-127598 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
Hen brain microsomal preparation has phenyl valeratehydrolyzing activity associated with neurotoxic esterase activity. Part of that activity is due to paraoxon-insensitive esterases and a sub-part of this is sensitive to neurotoxic organophosphates, i.e., mipafox and leptophosoxon. This neurotoxic agent sensitive esterase activity is referred to as neurotic esterase (NTE). Because of the commercial unavailability and high toxicity of mipafox, which is usually used as the selective inhibitor for assaying NTE, leptophosoxon was used as an alternative to mipafox. Results indicated that the NTE fraction of hen brain microsomal PV-hydrolyzing activity is the same target for either mipafox or leptophosoxon. The inhibitory effect of leptophosoxon against that fraction was much higher than that of mipafox. The availability of leptophos/leptophosoxon makes this assay very useful for screening organophosphorus esters for neurotoxic effects. |
Supplementary Notes |
Pub. in Jnl. of Analytical Toxicology, v5 p183-186 Jul/Aug 81. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Assay of Chicken Brain Neurotoxic Esterase Activity Using Leptophosoxon as the Selective Neurotoxic Inhibitor. |
PUB Date Free Form |
8 Jun 81 |
Category Codes |
6T; 6O; 57Y; 57Q |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323807822 |
Origin |
NTIS |
Type |
CAT |