| Main Title |
Dominant Lethal Assay of Chlordecone and Its Distribution in the Male Reproductive Tissues of the Rat. |
| Author |
Simon, G. S. ;
Egle, J. L. ;
Dougherty, R. W. ;
Borzelleca, J. F. ;
|
| CORP Author |
Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1986 |
| Report Number |
EPA-R-804290; EPA/600/J-86/168; |
| Stock Number |
PB87-117891 |
| Additional Subjects |
Reproduction(Biology) ;
Toxicology ;
Rats ;
Laboratory animals ;
Males ;
Tissues(Biology) ;
Bioassay ;
Reprints ;
Chlordecone
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-117891 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
Male rats received 3.6 or 11.4 mg/kg/day of chlordecone orally for 5 days. Some statistically significant events were seen in the reproductive data of females mated to males receiving chlordecone. However, these events did not follow a consistent pattern and do not suggest the conclusion that chlordecone causes dominant lethal effects. Male rats received a single oral dose (40 mg/kg) of chlordecone and were killed at 1, 2, 3, 5, 7, 14 or 21 days. Chlordecone was distributed throughout the reproductive tract. The descending order of concentration was seminal vesicular fluid > prostate > vas deferens > seminal vesicle > unwashed sperm > washed sperm. It is concluded that chlordecone is well distributed throughout the reproductive tract of the male rat, appears in the ejaculate, and does not appear to produce dominant lethal effects. |
| Supplementary Notes |
Pub. in Toxicology Letters 30, p237-245 Mar 86. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Dominant Lethal Assay of Chlordecone and Its Distribution in the Male Reproductive Tissues of the Rat. |
| PUB Date Free Form |
c1986 |
| Category Codes |
57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
703717263 |
| Origin |
NTIS |
| Type |
CAT |
