| Main Title |
Selection of Candidate Compounds for In vitro Teratogenesis Test Validation. |
| Author |
Smith, M. K. ;
Kimmel, G. L. ;
Kochhar, D. M. ;
Shepard, T. H. ;
Spielberg, S. P. ;
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;Hospital for Sick Children, Toronto (Ontario). ;Jefferson Medical Coll., Philadelphia, PA. ;National Center for Toxicological Research, Jefferson, AR. ;Washington Univ., Seattle. School of Medicine. |
| Year Published |
1983 |
| Report Number |
EPA/600/J-83/241; |
| Stock Number |
PB84-245562 |
| Additional Subjects |
Toxicology ;
In vitro analysis ;
Validation ;
Tests ;
In vivo analysis ;
Reprints ;
Teratogenesis
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-245562 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
22p |
| Abstract |
The Consensus Workshop on In Vitro Teratogenesis Testing recommended that test validation be facilitated by a listing of agents with defined teratogenicity; subsequently, a panel was convened to review and select such agents. This communication establishes a list of 47 compounds or conditions which demonstrate a wide range of teratogenicity in vivo. The agents were chosen primarily on the strength of the literature base denoting their in vivo effects. The tables note a number of general biological and toxicological characteristics for each agent, and the details of representative in vivo teratology studies are summarized and referenced. This list is intended to serve as a base for in vitro teratogenesis test validation and should prove useful in developing and identifying those systems which will contribute to a more effective testing program. |
| Supplementary Notes |
Prepared in cooperation with Hospital for Sick Children, Toronto (Ontario), Jefferson Medical Coll., Philadelphia, PA., National Center for Toxicological Research, Jefferson, AR., and Washington Univ., Seattle. School of Medicine. |
| Availability Notes |
Pub. in Teratogenesis, Carcinogenesis, and Mutagenesis 3, p461-480 1983. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Selection of Candidate Compounds for In vitro Teratogenesis Test Validation. |
| PUB Date Free Form |
c1983 |
| Category Codes |
6T; 57Y |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
435627038 |
| Origin |
NTIS |
| Type |
CAT |
