Main Title |
Neural Factors in the Development of Renal Function: Effect of Neonatal Central Catecholaminergic Lesions with 6-Hydroxydopamine. |
Author |
Gray, J. A. ;
Kavlock, R. J. ;
Seidler, F. J. ;
Slotkin, T. A. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA/600/J-91/325; |
Stock Number |
PB92-120492 |
Additional Subjects |
Vasopressin ;
Kidney ;
Catecholamines ;
Peripheral nerves ;
Body weight ;
Homeostasis ;
Rats ;
Newborn animals ;
Kidney concentrating ability ;
Organ weight ;
Water consumption ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-120492 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
Peripheral sympathetic neurons are thought to provide trophic regulatory signals for development of their target tissues. In the current study, the authors investigated the role of sympathetic tone in the functional development of the kidney in the rat, using intracisternal administration of 6-hydroxydopamine (6-OHDA). The treatment destroys central catecholaminergic pathways and permanently reduces sympathetic activity without ablating peripheral nerves terminals. Renal function was evaluated over the first two postnatal weeks, a period of rapid glomerular and tubular maturation, by tests of basal renal clearance, urinary concentrating ability in response to fluid deprivation, and the response to a vasopressin analog (DDAVP). Although basal renal clearance and the homeostatic response to fluid deprivation developed normally in the lesioned rats, the response to a maximally-effective dose of DDAVP was attenuated at the end of the second postnatal week, a time during which the normal response increased dramatically. |
Supplementary Notes |
Pub. in Jnl. of Developmental Physiology, v15 p325-330 Nov 91. Prepared in cooperation with Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Neural Factors in the Development of Renal Function: Effect of Neonatal Central Catecholaminergic Lesions with 6-Hydroxydopamine. |
Category Codes |
57Q; 57S; 57B |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
203825593 |
Origin |
NTIS |
Type |
CAT |