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RECORD NUMBER: 11 OF 11

Main Title Selected toxicological studies of dimilin in weanling male rats /
Author Patel, Yogendra M., ; Santolucito, John A.
Other Authors
Author Title of a Work
Santolucito, John A.,
CORP Author Environmental Monitoring Systems Lab., Las Vegas, NV.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Environmental Monitoring Systems Laboratory,
Year Published 1980
Report Number EPA-600/3-80-031
Stock Number PB80-177868
OCLC Number 06467303
Subjects Insecticides--Toxicology ; Pesticides--Toxicology ; Rats--Effect of insecticides on
Additional Subjects Toxicology ; Pesticides ; Rats ; Laboratory animals ; Reproductive system ; Histology ; Pathology ; Signs and symptoms ; Bioassay ; Tissues(Biology) ; Dosage ; Ingestion(Biology) ; Insecticides ; Nitrogen organic compounds ; Adrenal glands ; Testosterone ; Ureas ; Toxic substances ; Dimilin ; Benzamide/N-(((chlorophenyl) amino) carbonyl)-difluoro
Internet Access
Description Access URL
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=91019MTV.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EHAM  QP82.2.P6E2 600, 1980, no.31 Region 1 Library/Boston,MA 04/29/2016
EJBD  EPA 600-3-80-031 Headquarters Library/Washington,DC 04/01/2016
EKBD  EPA-600/3-80-031 Research Triangle Park Library/RTP, NC 07/18/2003
ELBD ARCHIVE EPA 600-3-80-031 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ESAD  EPA 600-3-80-031 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB80-177868 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vi, 8 pages ; figures, tables ; 28 cm.
Abstract The effects of the subacute doses of Dimilin (1(4-chlorophenyl)-3-(2,6-difluoropbenzyl)urea) on the reproductive system of weanling male rats were examined over a period of 96 days. The parameters evaluated were: plasma testosterone level, growth of reproductive organs (testes, prostate, seminal vesicles) and adrenal glands, and histological examination of tissues for pathological changes associated with the administration of Dimilin. The animals, 25 days old, were given 0, 15, 150, and 300 milligrams/kilogram/day of Dimilin suspension in vegetable oil by intragastric intubation for a period of 0, 14, 28, 42, and 96 days. The data indicate that Dimilin had no adverse effects on body weight or organ weights of weanling rats, but a decrease in circulating testosterone in the plasma of animals of prepubertal age was noted. However, this effect of Dimilin began to disappear with the onset of puberty. The histological examination of the test animals with lower circulating testerone in plasma failed to reveal any Dimilin-induced changes in interstitial or germinal cells. On the basis of these observations, it is concluded that Dimilin, at 15, 150, and 300 mg/kg/day dosage levels, transiently depresses the testosterone in plasma in the prepubertal period, yet has no delaying effects on the development of the reproductive organs.
Notes "February 1980." "This work was performed for EPA's Office of Toxic Substances, Washington, D.C." Includes bibliographical references (pages 7-8).
Place Published Las Vegas Springfield, Va.
Access Notes Also available via the World Wide Web.
Corporate Au Added Ent Environmental Monitoring Systems Laboratory (Las Vegas, Nev.).; United States. Environmental Protection Agency. Office of Research and Development.
Title Ser Add Ent Research reporting series. Ecological research ; EPA-600/3-80-031.
PUB Date Free Form 1980
Series Title Traced Research reporting series Ecological research ; EPA-600/3-80-031
Series Title Untraced Research reporting series. 3, Ecological research ; EPA-600/3-80-031
NTIS Prices PC A02/MF A01
BIB Level m
Medium unmediated
Content text
Carrier volume
Cataloging Source OCLC/T
Merged OCLC records 1225726026
OCLC Time Stamp 20160419143759
Language eng
SUDOCS Number EP 1.23:600/3-80-031
Origin OCLC
Type MERGE
OCLC Rec Leader 01763cam 2200421Ia 45020