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Main Title Evaluation of the Mutagenic Potentials of Platinum Compounds.
Author Sandhu, Shahbeg ;
CORP Author North Carolina Central Univ., Durham. Dept. of Biology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1979
Report Number EPA-R-803299; EPA-600/1-79-033;
Stock Number PB81-228181
Additional Subjects Mutagens ; Platinum inorganic compounds ; Environmental surveys ; Toxicology ; Metals ; Evaluation ; Mice ; Bioassay ; Mutagenesis ; Cell lines ; Toxic substances ; Platinum diaminodichloride ; Platinum diaminodinitrite ; Platinum dichloride ; Platinum tetrachloride
Library Call Number Additional Info Location Last
NTIS  PB81-228181 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 41p
Abstract Five platinum compounds, cis-platinum diaminodichloride (cis-PDD), trans-platinum diaminodichloride (trans-PDD), platinum diaminodinitrite, platinum dichloride (PtCl2), and platinum tetrachloride (PtCl4) were evaluated for their mutagenic activity at the thymidine kinase locus in the mouse lymphoma cells line L5178Y. Three of these compounds, i.e., cis-PDD, trans-PDD and PtCl4 yielded significantly higher mutagenic frequencies as compared to the control. Two platinum compounds, i.e., cis-PDD and PtCl4, were also judged to be mutagenic on the basis of results obtained in the Phaseolus mungo plant test system.
NTIS Title Notes Final rept..
PUB Date Free Form Aug 79
Category Codes 6T; 68; 57Y
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 323801463
Origin NTIS
Type CAT