||Polychlorinated Biphenyls as Inducers of Hepatic Microsomal Enzymes: Structure-Activity Rules.
Parkinson, A. ;
Robertson, L. ;
Safe, Lorna ;
Safe, S. ;
||Guelph Univ. (Ontario).;Environmental Research Lab.-Duluth, MN.
Molecular structure ;
Laboratory animals ;
In vivo analysis ;
Public health ;
Chlorine organic compounds ;
Polychlorinated biphenyls ;
Toxic substances ;
Chemical shifts(Nuclear magnetic resonance)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||A number of highly purified polychlorinated biphenyl (PCB) isomers and congeners were synthesized and administered to male Wistar rats at dosage levels of 30 and 150 micromol/kg. The effects of this in vivo treatment on the drug-metabolizing enzymes were determined by measuring the microsomal benzo(a)pyrene (B(a)P) hydroxylase, dimethylaminoantipyrine (DMAP) N-demethylase and NADPH-cytochrome c reductase enzyme activities, the cytochrome b sub 5 content and the relative peak intensities of spectral shifts of the reduced microsomal cytochrome P-450:CO and ethylisocyanide (EIC) binding difference spectra.
||Pub. in Chemico-Biological Interactions 30, p271-285 1981.
|NTIS Title Notes
||Reprint: Polychlorinated Biphenyls as Inducers of Hepatic Microsomal Enzymes: Structure-Activity Rules.
|PUB Date Free Form
||7D; 6E; 6T; 68G; 99F; 57U; 57Y
||Not available NTIS