Full Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Immunological Studies in Mice Following In utero Exposure to NiCl2.
Author Smialowicz, R. J. ; Rogers, R. R. ; Riddle, M. M. ; Rowe, D. G. ; Luebke, R. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/072;
Stock Number PB86-214863
Additional Subjects Nickel chloride ; Immunity ; Toxicology ; Bioassay ; Pregnancy ; Mice ; Laboratory animals ; Dosage ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB86-214863 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 14p
Abstract The effect that NiCl2 has on the development of immune function in mice was examined in the offspring of dams implanted with mini-osmotic pumps during pregnancy. Time bred C57BL/6J mice were implanted subcutaneously on day 5 of gestation with mini pumps which delivered a total dose of from 9.1 to 73.2 micrograms/g NiCl2. The pumps delivered NiCl2 to the dams through day 19 of gestation. At 8-10 weeks of age the offspring of NiCl2-dosed dams were evaluated for immune function. No consistent significant alterations were observed between control and treated offspring for the following: lymphoid organ or body weights; the lymphoproliferative response to B or T lymphocyte mitogens; the lymphoproliferative response to allogeneic spleen cells in the mixed lymphocyte reaction; the development of syngeneic tumors; or the primary antibody response to sheep red blood cells. Natural killer (NK) cell activity was reduced in offspring exposed to NiCl2 in utero; however, the biological relevance of these reductions is questionable because of the failure to demonstrate an increased susceptibility to the B16-F10 syngeneic tumor. The results indicate that under the conditions and doses employed it appears that NiCl2 does not adversely affect the developing immune system of the mouse.
Supplementary Notes Pub. in Toxicology 38, n3 p293-303 Mar 86.
NTIS Title Notes Journal article.
Title Annotations Reprint: Immunological Studies in Mice Following In utero Exposure to NiCl2.
PUB Date Free Form 1986
Category Codes 6E; 6T; 57J; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 624112930
Origin NTIS
Type CAT