Main Title |
Disposition of Mulberry Pollen in the Human Respiratory System: A Mathematical Model. |
Author |
Martonen, T. B. ;
O'Rourke, M. K. ;
|
CORP Author |
Arizona Univ., Tucson. Div. of Respiratory Sciences.;Health Effects Research Lab., Research Triangle Park, NC.;Center for Indoor Air Research, Linthicum, MD. |
Publisher |
1993 |
Year Published |
1993 |
Report Number |
EPA-R811806 ;EPA-90-003; EPA/600/J-94/065; |
Stock Number |
PB94-143765 |
Additional Subjects |
Pollen ;
Respiratory system ;
Environmental air pollutants ;
Air pollution effects(Humans) ;
Allergens ;
Pharmacokinetics ;
Respiration ;
Particles ;
Biological models ;
Reprints ;
Mulberry pollen
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB94-143765 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
Inhaled particle deposition sites must be identified to effectively treat human airway diseases. We have determined distribution patterns of a selected aeroallergen, mulberry pollen, among human extrathoracic (ET: i.e., oronasopharyngeal) regions and the lung. A predictive model validated by inhalation exposure data from human subjects was utilized. Deposition locations were primarily functions of (1) mulberry particle parameters (geometric size, 11-18 micrometers, shape, spherical; and density, 1.14 g/cu cm, and (2) mode of breathing. In the general population, two styles of inhalation are prevalent, normal augmentors (NAs) and mouth breathers (MBs). Their clinical definitions are based on intra-ET airflow divisions. For a NA-mode breathing sedentary (minute ventilation = V(sub E) = 10 L/min) adult, 93% of inhaled mulberry pollen was removed by the ET compartment and 7% collected within the lung. For a MB, the respective deposition efficiencies were 75% and 25%. To apply the model, we used a daily springtime mulberry pollen concentration of 1,748 grains/cu m and an exposure time of 0.5 hour to calculate actual doses for the respiratory system. Under the stipulated conditions, a MB would inhale 524 pollen grains per day and 131 would be deposited in the lung; the value is 37 grains for a NA. Preliminary epidemiological results suggest 15% of the study population are MBs in whom such pollen deposits are likely contributors to airway disease. |
Supplementary Notes |
Pub. in Grana 32, p290-301 1993. Sponsored by Health Effects Research Lab., Research Triangle Park, NC., and Center for Indoor Air Research, Linthicum, MD. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Disposition of Mulberry Pollen in the Human Respiratory System: A Mathematical Model. |
Category Codes |
68G; 68A; 57J |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
409121249 |
Origin |
NTIS |
Type |
CAT |