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OLS Field Name OLS Field Data
Main Title Evaluation of the Developmental Toxicity of Sodium Nitrite in Long-Evans Rats (Journal Version).
Author Roth, A. C. ; Herkert, G. E. ; Bercz, J. P. ; Smith, M. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1987
Year Published 1987
Report Number EPA/600/J-87/390;
Stock Number PB89-101109
Additional Subjects Toxic substances ; Nitrites ; Toxicity ; Hypochromic anemia ; Pregnancy ; Lactation ; Prenatal exposure delayed effects ; Laboratory animals ; Sodium inorganic compounds ; Mortality ; Exposure ; Hematology ; Growth ; Histology ; Pathology ; Liver ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB89-101109 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/14/1989
Collation 11p
Abstract Sodium nitrite administered in the drinking water to Long-Evans rats during pregnancy and lactation severely affected arythropoietic development, growth and mortality in their offspring. There were no significant differences between treated and control litters at birth. Thereafter, pups of treated dams on 2 and 3 q NaNO2/L gained less weight, progressively became severely anemic and began to die by the third week postpartum. By the second week postpartum, hemoglobin levels, RBC count, and MCV's of these pups were all drastically reduced compared to controls. Blood smears showed marked anisocytosis and hypochromasia. Gross chylous serum lipemia and fatty liver degeneration were noted. The data presented are consistent with the lactational induction of severe iron deficiency in the neonata.
Supplementary Notes Pub. in Fundamental and Applied Toxicology, v9 n4 p668-677 Nov 87.
NTIS Title Notes Journal article.
Title Annotations Reprint: Evaluation of the Developmental Toxicity of Sodium Nitrite in Long-Evans Rats (Journal Version).
Category Codes 57Y; 57H; 44G; 68G
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 833024104
Origin NTIS
Type CAT