||Evaluation of the Developmental Toxicity of Sodium Nitrite in Long-Evans Rats (Journal Version).
Roth, A. C. ;
Herkert, G. E. ;
Bercz, J. P. ;
Smith, M. K. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Toxic substances ;
Hypochromic anemia ;
Prenatal exposure delayed effects ;
Laboratory animals ;
Sodium inorganic compounds ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Sodium nitrite administered in the drinking water to Long-Evans rats during pregnancy and lactation severely affected arythropoietic development, growth and mortality in their offspring. There were no significant differences between treated and control litters at birth. Thereafter, pups of treated dams on 2 and 3 q NaNO2/L gained less weight, progressively became severely anemic and began to die by the third week postpartum. By the second week postpartum, hemoglobin levels, RBC count, and MCV's of these pups were all drastically reduced compared to controls. Blood smears showed marked anisocytosis and hypochromasia. Gross chylous serum lipemia and fatty liver degeneration were noted. The data presented are consistent with the lactational induction of severe iron deficiency in the neonata.
||Pub. in Fundamental and Applied Toxicology, v9 n4 p668-677 Nov 87.
|NTIS Title Notes
||Reprint: Evaluation of the Developmental Toxicity of Sodium Nitrite in Long-Evans Rats (Journal Version).
||57Y; 57H; 44G; 68G
||PC A03/MF A01