Main Title |
Central Adrenergic Receptor Changes in the Inherited Noradrenergic Hyperinnervated Mutant Mouse Tottering (Journal Version). |
Author |
Levitt, P. ;
Lau, C. ;
Pylypiw, A. ;
Ross, L. L. ;
|
CORP Author |
Medical Coll. of Pennsylvania, Philadelphia.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1987 |
Year Published |
1987 |
Report Number |
EPA-68-02-4032 ;EPA-68-02-4450; EPA/600/J-87/410; |
Stock Number |
PB89-105563 |
Additional Subjects |
Brain ;
Adrenergic receptors ;
Epilepsy ;
Locus coeruleus ;
Neurons ;
Petit mal epilepsy ;
Laboratory animals ;
Norepinephrine ;
Alpha adrenergic receptors ;
Beta adrenergic receptors ;
Spinal cord ;
Hippocampus ;
Cerebellum ;
Reprints ;
Tottering mice ;
Neurologic mutants
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-105563 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
Adrenergic receptor binding characteristics were analyzed in the mutant mouse tottering (tg/tg), a single gene locus autosomal recessive mutation causing hyperinnervation by locus coeuruleus neurons of their target regions, which results in epilepsy. Instead of the expected down-regulation of receptors due to the hyperinnervation, both 3H-prazosin (alpha 1-receptor) and 125I-iodopindolol (beta-receptor) binding were normal in the tg/tg hippocampus, spinal cord and slightly increased in the cerebellum. The lack of postsynaptic receptor modulation in the target cells, combined with increased levels of norepinephrine due to the aberrant axon growth, may be critical factors in the expression of the abnormal spike-wave absence seizures in the tg/tg mouse. (Copyright (c) 1987 Elsevier Science Publishers B.V.) |
Supplementary Notes |
Pub. in Brain Research, v418 p174-177 1987. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Central Adrenergic Receptor Changes in the Inherited Noradrenergic Hyperinnervated Mutant Mouse Tottering (Journal Version). |
Category Codes |
57S; 57S |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
833027487 |
Origin |
NTIS |
Type |
CAT |