Main Title |
Development of Serotonergic and Adrenergic Receptors in the Rat Spinal Cord: Effects of Neonatal Chemical Lesions and Hyperthyroidism. |
Author |
Lau, C. ;
Pylypiw, A. ;
Ross, L. L. ;
|
CORP Author |
Medical Coll. of Pennsylvania, Philadelphia.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA/600/J-85/085; |
Stock Number |
PB85-239408 |
Additional Subjects |
Spinal cord ;
Rats ;
Laboratory animals ;
Hyperthyroidism ;
Reprints ;
Serotonergic receptors ;
Adrenergic receptors
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-239408 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
11p |
Abstract |
The ontogeny of serotonergic receptors and alpha- and beta-adrenergic receptors in thoracolumbar spinal cord of rats given neurotoxins which destroy serotonergic (5,7-dihydroxytryptamine (5,7-DHT) or noradrenergic (6-hydroxydopamine (6-OHDA)) nerve terminals was examined. Intracisternal administration of 5,7-DHT or 6-OHDA at 1 and 6 days of age prevented, respectively, the development of 5-HT and CA levels in the spinal cord. Rats lesioned with 5,7-DHT displayed a marked elevation of 5-HT receptors with a binding of 50% greater than controls at 1 week and a continuing increase to twice normal by 4 weeks. A similar pattern of up-regulation was also detected with the alpha-adrenergic receptor, as rats lesioned with 6-OHDA exhibited persistent increases in receptor concentration. However, in these same animals ontogeny of the beta-adrenergic receptor in the spinal cord remained virtually unaffected by the chemical lesion. Neonatal treatment of triiodothyronine on the other hand was capable of evoking persistent increases in beta-adrenergic receptor binding. |
Availability Notes |
Pub. in Developmental Brain Research 19, p57-66 1985. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Development of Serotonergic and Adrenergic Receptors in the Rat Spinal Cord: Effects of Neonatal Chemical Lesions and Hyperthyroidism. |
PUB Date Free Form |
c1985 |
Category Codes |
6E; 57E |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
529825038 |
Origin |
NTIS |
Type |
CAT |