Main Title |
CASE: The Computer-Automated Structure Evaluation System, as an Alternative to Extensive Animal Testing. |
Author |
Rosenkranz, H. S. ;
Klopman, G. ;
|
CORP Author |
Case Western Reserve Univ., Cleveland, OH.;Health Effects Research Lab., Cincinnati, OH. |
Publisher |
c1988 |
Year Published |
1988 |
Report Number |
EPA-R-812264; EPA/600/J-88/407; |
Stock Number |
PB90-111550 |
Additional Subjects |
Toxicology ;
Substitutes ;
Diagnostic routines ;
Reprints ;
Computer automated structure evaluation(CASE) ;
Carcinogenicity tests ;
Animal testing alternatives ;
Computer applications ;
Structure-activity relationship
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-111550 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
CASE, an artificial intelligence system with demonstrated ability to predict biological activity based on structural considerations, correctly predicts animal carcinogenicity. It can, therefore, play a pivotal role in classifying chemicals as carcinogens and prioritizing them for further testing. Additionally, CASE shows promise in the design of pharmacologically active agents by reducing the number of drugs that need to be synthesized and tested. For both of these applications, CASE provides a mechanism to conserve animal and other testing resources. |
Supplementary Notes |
Pub. in Jnl. of Toxicology and Industrial Health, v4 n4 p533-540 1988. Sponsored by Health Effects Research Lab., Cincinnati, OH. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: CASE: The Computer-Automated Structure Evaluation System, as an Alternative to Extensive Animal Testing. |
Category Codes |
57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
935218782 |
Origin |
NTIS |
Type |
CAT |