| Main Title |
Altered Maternal Zinc Metabolism Following Exposure to Diverse Developmental Toxicants (Revised). |
| Author |
Taubeneck, M. W. ;
Daston, G. P. ;
Rogers, J. M. ;
Keen, C. L. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;California Univ., Davis. ;Procter and Gamble Co., Cincinnati, OH. Miami Valley Labs.;National Institutes of Health, Bethesda, MD.;Department of Agriculture, Washington, DC. |
| Publisher |
c1994 |
| Year Published |
1994 |
| Report Number |
EPA/600/J-94/400; NIH-HD01743; |
| Stock Number |
PB95-126447 |
| Additional Subjects |
Zinc ;
Metabolism ;
Toxicity ;
Rats ;
Maternal exposure ;
Nutrition ;
Biological effects ;
Maternal-fetal exchange ;
Dose-response relationships ;
Food consumption ;
Statistical analysis ;
Urethane ;
Arsenic ;
Alcohols ;
Melphalan ;
Metallothionein ;
Reprints ;
Alpha-hederin ;
Acute phase response
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB95-126447 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
20p |
| Abstract |
The hypothesis that hepatic metallothionein (MT) induction in the pregnant animal results in a zinc (Zn) deficiency in the embryo was tested by treating pregnant rats with alpha-hederin, reported to induce MT in rat liver. Morphological development was assessed in term fetuses. A single dose of alpha-hederin, of 3-300 micromodes/kg, caused a dosage-related increase in maternal hepatic MT. These data support the hypothesis that systematic changes in Zn status, brought about by induction of hepatic MT, maybe a mechanism for maternally-mediated abnormal development. |
| Supplementary Notes |
Pub. in Reproductive Toxicology, v8 n1 p25-40 Feb 94. See also AD-A266 504. Prepared in cooperation with California Univ., Davis. and Procter and Gamble Co., Cincinnati, OH. Miami Valley Labs. Sponsored by National Institutes of Health, Bethesda, MD. and Department of Agriculture, Washington, DC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Altered Maternal Zinc Metabolism Following Exposure to Diverse Developmental Toxicants (Revised). |
| Category Codes |
57B; 57Y; 57S |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
433519169 |
| Origin |
NTIS |
| Type |
CAT |
