| Main Title |
Effects of Prenatal Nitrofen Exposure on Cardiac Structure and Function in the Rat. |
| Author |
Lau, C. ;
Cameron, A. M. ;
Irsula, O. ;
Robinson, K. S. ;
|
| CORP Author |
Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1986 |
| Year Published |
1986 |
| Report Number |
EPA-68-02-4032; EPA/600/J-86/484; |
| Stock Number |
PB89-105407 |
| Additional Subjects |
Toxic substances ;
Herbicides ;
Teratogens ;
Toxicity ;
Prenatal exposure delayed effects ;
Electrocardiography ;
Heart rate ;
Pregnancy ;
Chlorine organic compounds ;
Ethers ;
Respiration ;
Heart ;
Laboratory animals ;
Reprints ;
Nitrofen ;
Benzene/dichloro-nitrophenoxy
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-105407 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
The herbicide nitrofen was administered to pregnant Fischer-344 and Sprague-Dawley rats on days 10-13 of gestation (po., 20 or 40 mg/kg daily) and its effects on cardiac structure and function were investigated in the offspring. In the 21-day fetuses, nitrofen did not influence intrauterine growth or basal heart rate. In contrast, the herbicide produced a marked depression of heart rate and abnormal electrocardiographic (ECG) profiles in the newborn rats, in conjunction with labored respiratory movements and a profound increase of postnatal mortality. A few animals displayed cardiac ventricular septal defects and diaphragmatic hernias but these malformations did not appear to be associated with the ECG changes. The chronotropic deficiencies seen in the nitrofen-treated pups were reversible by acute hyperoxia (40% oxygen). These results suggest that the teratogenic effects of nitrofen on cardiac physiology and postnatal mortality cannot be accounted for solely by specific gross anatomical damages to the rat heart and diaphragm. (Copyright (c) 1986 by Academic Press, Inc.) |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology, v86 p22-32 1986. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effects of Prenatal Nitrofen Exposure on Cardiac Structure and Function in the Rat. |
| Category Codes |
57Y; 57U; 44G; 68G |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
834421628 |
| Origin |
NTIS |
| Type |
CAT |
