Main Title |
Multiple Effects of Ethane Dimethanesulfonate on the Epididymis of Adult Rats. |
Author |
Klinefelter, G. R. ;
Laskey, J. W. ;
Roberts, N. R. ;
Slott, V. ;
Suarez, J. D. ;
|
CORP Author |
NSI, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Reproductive Toxicology Branch. |
Publisher |
c1990 |
Year Published |
1990 |
Report Number |
EPA-68-02-4450; EPA/600/J-90/284; |
Stock Number |
PB91-144691 |
Additional Subjects |
Toxicity ;
Epididymis ;
Rats ;
Electron microscopy ;
Dose-response relationships ;
Spermatozoa ;
Cell survival ;
Leydig cells ;
Sperm motility ;
Morphology ;
Membrane proteins ;
Sex hormones ;
Testis ;
Organ weight ;
Infertility ;
Reprints ;
Ethane dimethanesulfonate
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-144691 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
19p |
Abstract |
Ethane dimethanesulfonate (EDS), a compound cytotoxic to Leydig cells which causes transient infertility, was used in a 4 d post-exposure experimental protocol designed to identify any effects this compound might exert on the epididymis. The techniques of efferent duct ligation and testosterone(T) implantation were used to negate the role of testicular effects on the epididymal parameters. EDS was shown to affect the epididymis in a dose-dependent fashion. The action of EDS on the epididymis is in part due to the androgen deprivation caused by the elimination of Leydig cells in the testis since T implantation prevented some of the morphological changes in the epididymis, as well as some of the changes in sperm proteins and motility. However, neither efferent duct ligation nor T implanatation prevented the formation of sperm granulomas in the caput epididymis, the distinct morphological alterations of the corpus epididymis, the modification of certain sperm membrane proteins, or the decrease in the progressive motility and velocity of sperm following EDS treatment. |
Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology, v105 n2 p271-287 Sep 90. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Reproductive Toxicology Branch. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Multiple Effects of Ethane Dimethanesulfonate on the Epididymis of Adult Rats. |
Category Codes |
57Y; 68G |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
109129693 |
Origin |
NTIS |
Type |
CAT |