||Ten- and Ninety-Day Toxicity Studies of 1,2-Dichlorobenzene Administered by Oral Gavage to Sprague-Dawley Rats.
Robinson, M. ;
Bercz, J. P. ;
Ringhand, H. P. ;
Condie, L. W. ;
Parnell., M. J. ;
||Health Effects Research Lab., Cincinnati, OH. ;Army Dugway Proving Ground, UT. ;Air Force Aerospace Medical Research Lab., Wright-Patterson AFB, OH.
Health hazards ;
Dose-response relationships ;
Body weight ;
Organ weight ;
Environmental pollutants ;
||Some EPA libraries have a fiche copy filed under the call number shown.
||Subacute (10-day) and subchronic (90-day) toxicity studies of 1,2-dichlorobenzene (DCB) were conducted in male and female Sprague-Dawley rats. 1,2-Dichlorobenzene was administered in corn oil by oral gavage; control animals received corn oil. At time of sacrifice, gross necropsies were performed and selected tissues were weighed and prepared for histological evaluation. Blood was taken for hematology and clinical chemistry determinations. While there were no definitive dose-related histopathological findings in the subacute study, the data did show a tendency toward an increased frequency of hepatocellular cytoplasmic alterations and vacuolization, and single cell necrosis. In the subchronic study, hepatocellular changes associated with treatment included centrolobular degeneration and hypertrophy, and single cell necrosis in the high dose males and females. Correlating effects observed in clinical chemistry and histopathology with other studies, demonstrate that the liver and kidney are the target organs of 1,2-dichlorobenzene toxicity in the rat.
||Pub. in Drug and Chemical Toxicology, v14 n1-2 p83-112 Mar 91. Prepared in cooperation with Army Dugway Proving Ground, UT., and Air Force Aerospace Medical Research Lab., Wright-Patterson AFB, OH.
|NTIS Title Notes
||Reprint: Ten- and Ninety-Day Toxicity Studies of 1,2-Dichlorobenzene Administered by Oral Gavage to Sprague-Dawley Rats.
||PC A03/MF A01