| Main Title |
Immune Function in Adult C57BL/6J Mice Following Exposure to Urethan Pre- or Postnatally. |
| Author |
Luebke, R. W. ;
Riddle, M. M. ;
Rogers, R. R. ;
Rowe, D. G. ;
Garner, R. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/174; |
| Stock Number |
PB87-115127 |
| Additional Subjects |
Drugs ;
Toxicology ;
Neoplasms ;
Mice ;
Laboratory animals ;
Reprints ;
Urethan ;
Immune response
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-115127 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
Administration of urethan (URE or ethyl carbamate) to mice results in the development of a variety of tumors, and, in certain strains of mice, marked supression of the immune response. Perinatal exposure of mice to URE has been found to result in increased tumor induction compared to exposure of adult animals. In the present study, the effects of perinatal exposure to URE on the development of immunocompetence was investigated. Pregnant mice were injected with total doses of either 0.5 or 1.0 mg URE/g of body weight over days 7-16 of gestation or pups of nontreated dams were administered a total dose of 2.0 mg URE/g of body weight over postpartum days 5-14. Postnatal exposure to URE suppressed NK (natural killer) cell activity but left intact other measured parameters of the host defense system. Prenatal exposure, on the other hand, resulted in elevated leukocyte counts and a trend toward increased spleen and thymus size in offspring of treated mothers. |
| Supplementary Notes |
Pub. in Jnl. of Immunopharmacology 8, n2 p243-257 1986. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Immune Function in Adult C57BL/6J Mice Following Exposure to Urethan Pre- or Postnatally. |
| PUB Date Free Form |
c1986 |
| Category Codes |
57J |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
703715381 |
| Origin |
NTIS |
| Type |
CAT |
