Main Title |
Augmentation of Murine Natural Killer Cell Activity by Manganese Chloride. |
Author |
Rogers, R. ;
Garner, R. ;
Riddle, M. ;
Luebke, R. ;
Smialowicz, R. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1983 |
Report Number |
EPA/600/J-83-121; |
Stock Number |
PB84-123801 |
Additional Subjects |
Toxicology ;
Cells(Biology) ;
Spleen ;
Mice ;
Activity ;
In vitro analysis ;
In vivo analysis ;
Reprints ;
Manganese chlorides ;
Cytotoxicity
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-123801 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
Natural Killer (NK) cell activity of spleen cells from male CBA/J mice was augmented by a single parenteral injection of MnCl2 administered 1 day prior to testing by in vitro and in vivo isotope release assays. Increased cytotoxic activity was observed in vitro against both NK-sensitive (YAC-1) and NK-resistant (EL-4) target cells. NK activity was also enhanced in normally low (A/J) and intermediately (C57B1/6J) reactive strains of mice. Augmentation of NK activity by MnCl2 was accompanied by an increase in circulating interferon (IFN) levels. |
Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 70, p7-17 1983. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Augmentation of Murine Natural Killer Cell Activity by Manganese Chloride. |
PUB Date Free Form |
1983 |
Category Codes |
6T; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
404821569 |
Origin |
NTIS |
Type |
CAT |