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RECORD NUMBER: 5 OF 11

OLS Field Name OLS Field Data
Main Title Influence of Time of Exposure to Carbon Tetrachloride on Toxic Liver Injury.
Author Bruckner, J. V. ; Luthra, R. ; Kyle, G. M. ; Muralidhara, S. ; Ramanathan, R. ;
CORP Author Georgia Univ., Athens. Dept. of Pharmacology and Toxicology. ;Texas Univ., Austin. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-R-811215; EPA/600/J-84/272;
Stock Number PB85-220424
Additional Subjects Toxicology ; Injuries ; Exposure ; Liver ; Rats ; Laboratory animals ; Reprints ; Carbon tetrachloride ; Hepatotoxins
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB85-220424 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 7p
Abstract The study was conducted to determine whether, and by what mechanisms, time of exposure could influence the ability of a model hepatotoxin, carbon tetrachloride (CCl4) to cause liver injury. Rats dosed orally with CCl4 during their active/dark cycle were found to be more susceptible to liver injury than rats dosed during their inactive/light cycle. There was greater hepatic microsomal uptake and metabolism of CCl4 in rats dosed during their active cycle.
Supplementary Notes Prepared in cooperation with Texas Univ., Austin. Dept. of Pharmacology.
Availability Notes Pub. in Ann. Rev. Chronopharmacol. 1, p373-376 1984.
NTIS Title Notes Journal article.
Title Annotations Reprint: Influence of Time of Exposure to Carbon Tetrachloride on Toxic Liver Injury.
PUB Date Free Form c1984
Category Codes 6T; 6E; 57Y; 57O
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 525518788
Origin NTIS
Type CAT